The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease
Identifieur interne : 001315 ( Main/Exploration ); précédent : 001314; suivant : 001316The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease
Auteurs : Magdalena Eriksson Domellöf [Suède] ; Eva Elgh [Suède] ; Lars Forsgren [Suède]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-10.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Aged, Cognition, Cognition Disorders (etiology), Cognitive disorder, Female, Gait Disorders, Neurologic (etiology), Human, Humans, Hypokinesia (etiology), Male, Memory (physiology), Middle Aged, Motor system disorder, Nervous system diseases, Neuropsychological Tests, Parkinson Disease (complications), Parkinson disease, Parkinson's disease, Regression Analysis, Sensation Disorders (etiology), Severity of Illness Index, Tremor (etiology), cognition, newly diagnosed, population based.
- MESH :
- complications : Parkinson Disease.
- etiology : Cognition Disorders, Gait Disorders, Neurologic, Hypokinesia, Sensation Disorders, Tremor.
- physiology : Memory.
- Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Regression Analysis, Severity of Illness Index.
Abstract
Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23814
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000301
- to stream Istex, to step Curation: 000301
- to stream Istex, to step Checkpoint: 000047
- to stream PubMed, to step Corpus: 001136
- to stream PubMed, to step Curation: 001136
- to stream PubMed, to step Checkpoint: 001029
- to stream Ncbi, to step Merge: 003292
- to stream Ncbi, to step Curation: 003292
- to stream Ncbi, to step Checkpoint: 003292
- to stream Main, to step Merge: 001368
- to stream PascalFrancis, to step Corpus: 000390
- to stream PascalFrancis, to step Curation: 002928
- to stream PascalFrancis, to step Checkpoint: 000353
- to stream Main, to step Merge: 001943
- to stream Main, to step Curation: 001315
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title>
<author><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name>
</author>
<author><name sortKey="Elgh, Eva" sort="Elgh, Eva" uniqKey="Elgh E" first="Eva" last="Elgh">Eva Elgh</name>
</author>
<author><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</idno>
<date when="2011" year="2011">2011</date>
<idno type="doi">10.1002/mds.23814</idno>
<idno type="url">https://api.istex.fr/document/774A8B62AAECE9DC80F22568F3B0126F87EA7CC9/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000301</idno>
<idno type="wicri:Area/Istex/Curation">000301</idno>
<idno type="wicri:Area/Istex/Checkpoint">000047</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Domellof M:the:relation:between</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:21661051</idno>
<idno type="wicri:Area/PubMed/Corpus">001136</idno>
<idno type="wicri:Area/PubMed/Curation">001136</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001029</idno>
<idno type="wicri:Area/Ncbi/Merge">003292</idno>
<idno type="wicri:Area/Ncbi/Curation">003292</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003292</idno>
<idno type="wicri:Area/Main/Merge">001368</idno>
<idno type="wicri:source">INIST</idno>
<idno type="RBID">Pascal:11-0481149</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000390</idno>
<idno type="wicri:Area/PascalFrancis/Curation">002928</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000353</idno>
<idno type="wicri:doubleKey">0885-3185:2011:Domellof M:the:relation:between</idno>
<idno type="wicri:Area/Main/Merge">001943</idno>
<idno type="wicri:Area/Main/Curation">001315</idno>
<idno type="wicri:Area/Main/Exploration">001315</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease</title>
<author><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Elgh, Eva" sort="Elgh, Eva" uniqKey="Elgh E" first="Eva" last="Elgh">Eva Elgh</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name>
<affiliation wicri:level="1"><country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Pharmacology and Clinical Neuroscience, Umeå University, Umeå</wicri:regionArea>
<wicri:noRegion>Umeå</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Movement Disorders</title>
<title level="j" type="abbrev">Mov. Disord.</title>
<idno type="ISSN">0885-3185</idno>
<idno type="eISSN">1531-8257</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2011-10">2011-10</date>
<biblScope unit="vol">26</biblScope>
<biblScope unit="issue">12</biblScope>
<biblScope unit="page" from="2183">2183</biblScope>
<biblScope unit="page" to="2189">2189</biblScope>
</imprint>
<idno type="ISSN">0885-3185</idno>
</series>
<idno type="istex">774A8B62AAECE9DC80F22568F3B0126F87EA7CC9</idno>
<idno type="DOI">10.1002/mds.23814</idno>
<idno type="ArticleID">MDS23814</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0885-3185</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Cognition</term>
<term>Cognition Disorders (etiology)</term>
<term>Cognitive disorder</term>
<term>Female</term>
<term>Gait Disorders, Neurologic (etiology)</term>
<term>Human</term>
<term>Humans</term>
<term>Hypokinesia (etiology)</term>
<term>Male</term>
<term>Memory (physiology)</term>
<term>Middle Aged</term>
<term>Motor system disorder</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Regression Analysis</term>
<term>Sensation Disorders (etiology)</term>
<term>Severity of Illness Index</term>
<term>Tremor (etiology)</term>
<term>cognition</term>
<term>newly diagnosed</term>
<term>population based</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term>
<term>Gait Disorders, Neurologic</term>
<term>Hypokinesia</term>
<term>Sensation Disorders</term>
<term>Tremor</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Memory</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Regression Analysis</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cognition</term>
<term>Homme</term>
<term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Trouble cognitif</term>
<term>Trouble moteur</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Recent studies have reported cognitive decline to be common in the early phase of Parkinson's disease. Imaging data connect working memory and executive functioning to the dopamine system. It has also been suggested that bradykinesia is the clinical manifestation most closely related to the nigrostriatal lesion. Exploring the relationship between motor dysfunction and cognition can help us find shared or overlapping systems serving different functions. This relationship has been sparsely investigated in population‐based studies of untreated Parkinson's disease. The aim of the present study was to investigate the association between motor signs and cognitive performance in the early stages of Parkinson's disease before the intake of dopaminergic medication. Patients were identified in a population‐based study of incident cases with idiopathic parkinsonism. Patients with the postural instability and gait disturbances phenotype were compared with patients with the tremor‐dominant phenotype on demographics and cognitive measures. Associations between cognitive and motor scores were investigated, with age, education, and sex controlled for. Bradykinesia was associated with working memory and mental flexibility, whereas axial signs were associated with episodic memory and visuospatial functioning. No significant differences in the neuropsychological variables were found between the postural instability and gait disturbances phenotype and the tremor phenotype. Our results indicate a shared system for slow movement and inflexible thinking that may be controlled by a dopaminergic network different from dopaminergic networks involved in tremor and/or rigidity. The association between axial signs and memory and visuospatial function may point to overlapping systems or pathologies related to these abilities. © 2011 Movement Disorder Society</div>
</front>
</TEI>
<affiliations><list><country><li>Suède</li>
</country>
</list>
<tree><country name="Suède"><noRegion><name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name>
</noRegion>
<name sortKey="Domellof, Magdalena Eriksson" sort="Domellof, Magdalena Eriksson" uniqKey="Domellof M" first="Magdalena Eriksson" last="Domellöf">Magdalena Eriksson Domellöf</name>
<name sortKey="Elgh, Eva" sort="Elgh, Eva" uniqKey="Elgh E" first="Eva" last="Elgh">Eva Elgh</name>
<name sortKey="Forsgren, Lars" sort="Forsgren, Lars" uniqKey="Forsgren L" first="Lars" last="Forsgren">Lars Forsgren</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001315 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001315 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= MovDisordV3 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:774A8B62AAECE9DC80F22568F3B0126F87EA7CC9 |texte= The relation between cognition and motor dysfunction in drug‐naive newly diagnosed patients with Parkinson's disease }}
This area was generated with Dilib version V0.6.23. |